Successful rational selective inhibition of a trypanosomal enzyme

Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.

The potency of a series of sulfonamide tubulin inhibitors against the growth of Trypanosoma brucei (T. brucei), as well as human cancer and primary fibroblast cells were evaluated with the aim of determining whether compounds that selectively inhibit parasite proliferation could be identified. Several compounds showed excellent selectivity against T. brucei growth, and have the potential to be ...

assessment of deep word knowledge in elementary and advanced iranian efl learners: a comparison of selective and productive wat tasks

testing plays a vital role in any language teaching program. it allows teachers and stakeholders, including program administrators, parents, admissions officers and prospective employers to be assured that the learners are progressing according to an accepted standard (douglas, 2010). the problems currently facing language testers have both practical and theoretical implications but the first i...

STUDYING THE BEHAVIOR OF SOLUTIONS OF A SECOND-ORDER RATIONAL DIFFERENCE EQUATION AND A RATIONAL SYSTEM

In this paper we investigate the behavior of solutions, stable and unstable of the solutions a second-order rational difference equation. Also we will discuss about the behavior of solutions a the rational system, we show these solutions may be stable or unstable.  

Co - evolutionary analysis enables rational deregulation of allosteric enzyme 1 inhibition in

Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications

Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease. In this work we identify small molecule inhibitors of a non-coding RNA uridylylation pathway. The TUTase family of enzymes is important for modulating non-coding RNA pathways in bo...